Music-based interventions can be effective rehabilitation training for enhancing motor and cognitive functions and mental health. Although the interventions were traditionally delivered in clinical settings, mobile applications have created an opportunity to deliver the music-based interventions at home to increase patient rehabilitation access and decrease transportation costs. Building off our prior work, we are continuing to refine and evaluate a user-friendly, engaging, customizable, in-home music-based training app for individuals with stroke. We expect to demonstrate the feasibility and efficacy of our training app to improve functional outcomes of stroke survivors with upper extremity impairments. One of our longer-term goals is to provide the app with effective stroke-specific music exercises with integrated artificial intelligence (AI) to frequently adapt rehabilitation training based on an individual’s progress to provide the best home training needed for stroke survivors.